Objective: To address this gap, we conducted a pre-registered meta-analysis to synthesize findings from rigorously designed randomized controlled trials (i.e., low attrition, comparable baseline ...

Many systematic reviews contain problematic randomised controlled trials (RCTs). These are studies with false data or results, which could be caused by research misconduct (such as data fabrication) ...

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

cHospital Israelita Albert Einstein and Lipid Clinic Heart Institute, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil ...

As a public health practitioner, you are considering how public health interventions might encourage individuals and families to reduce their salt intake to improve blood pressure among local ...

STRENGTHS AND LIMITATIONS OF THIS STUDY This is a large-scale, randomised controlled trial comparing personalised cardiac rehabilitation with usual care. The trial utilises an opt-out approach, ...

Acanthosis nigricans (AN) is a skin disorder marked by darkening and thickening of the skin, often linked to metabolic abnormalities. This systematic review of randomized controlled trials (RCTs) ...

Objective To investigate the effectiveness of cryotherapy on pain intensity, range of motion (ROM), swelling and function in the postoperative care of musculoskeletal disorders. Design Systematic ...

Objective To investigate the efficacy and safety of open-label placebos (OLP) in premenstrual syndrome (PMS). Design Randomised controlled trial. Setting Switzerland, 2018–2020. Participants 150 women ...

A new tool to identify problematic trials is now available, enabling researchers to check whether studies are trustworthy before including them in systematic reviews. The INSPECT-SR tool ...

Elemento is the director of the Englander Institute for Precision Medicine at Weill Cornell Medicine. Sternberg is the clinical director of the Englander Institute for Precision Medicine. Khozin is ...

“Well, we don’t have as much evidence as we would like on steroid use during pregnancy,” the obstetrician warned my co-author, Natalia Emanuel, as she wrote a prescription for inhaled corticosteroids ...