We explore what allosteric modulators are, their benefits and drawbacks, and which candidates are currently advancing through ...

Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a chronic and relapsing condition with complex pathogenesis and limited therapeutic options. The efficacy of ...

X-prolyl aminopeptidase 2 (XPNPEP2), which is abundantly expressed in vascular endothelial cells (ECs), has been reported to be associated with cardiovascular disease and angiogenesis. However, its ...

Fig. 1 Neural array imaging system and its principle behind its ability to break the trade-off between aperture size, ffeld of view, and imaging quality. (a) The system consists of a metalens array, a ...

Designing efficient transfer channels in the photoanodes of photocatalytic fuel cells is an innovative approach to achieving directional charge migration and shortening transmission pathways, ...

AN ENLIGHTENING session delivered at the annual United European Gastroenterology (UEG) Week 2025, held in Berlin, Germany, brought together leading experts to explore the functional outputs of the gut ...

Background: Cardiomyocytes produce histidyl dipeptides such as carnosine (β-alanyl-L-histidine) and anserine (β-alanyl-N π-methylhistidine) via carnosine synthase (CARNS) that are known to conjugate ...

Department of Chemistry, Farook College (Autonomous), Research Centre of University of Calicut, Kozhikode, Kerala 673632, India ...

This important work begins to understand how BDNF regulates the phosphorylation and activity of LRRK2. The overall strength of evidence has been assessed as compelling, though some claims are only ...

School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, P. R. China ...