The digital transformation of education has fundamentally changed how learning communities are conceptualized in online and blended environments. The seminal Community of Inquiry (CoI) framework ...

Mapping transcription factor (TF) binding sites across the genome is key to understanding how cells control gene expression, yet pinpointing their footprints across the genome—especially in single ...

Loop extrusion has emerged as a fundamental process to maintain chromosome structure and dynamics. The molecular heterogeneity and cooperative effects within an ATP-modulated, multicomponent ...

Nimodipine has shown neuroprotective effects in several studies; however, the specific targets and mechanisms remain unclear. This study aims to explore the potential targets and mechanisms of ...

Translation of the genetic code into proteins by ribosomes is essential for life. Due to the risk of protein misfolding, ribosomes require assistance from cotranslational processing factors, but how ...

The nuclear poly(A) binding protein (PABPN1) is a ubiquitously expressed, evolutionarily conserved protein that actively involved in 3’-poly(A) tail elongation and alternative polyadenylation (ApA).

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play a critical role in regulating neuronal and cardiac rhythmicity, with their function being modulated by cyclic nucleotide ...