Homozygous but not heterozygous loss of Pten in sporadic mouse models of SHH-medulloblastoma greatly accelerates tumor formation, not metastasis, through increased survival of differentiated cells and ...

引言从正常的组织修复滑向失控的恶性肿瘤时，我们往往会陷入一种线性的思维定势：以为这是一场由基因突变不断累积而直接导致的细胞“叛变”。然而，真实的生命图景远比这复杂得多。4月15日，《Cell》的研究报道“Oncogenic and ...