引言在当今的生物医药领域，我们正处于一场静悄悄却惊心动魄的变革之中。长久以来，药物研发的中心法则几乎都围绕着蛋白质展开，但人类基因组中只有约1.5%的序列编码蛋白质，而绝大多数基因转录为非编码RNA。这片浩瀚的“暗物质”海洋中，蕴藏着无数调控疾病的关 ...

Artificial intelligence (AI) and machine learning are increasingly being applied in the field of RNA biology. These methods are used to predict RNA structures, interactions with proteins and small ...

Researchers identify a shared RNA-protein interaction that could lead to broad-spectrum antiviral treatments for ...

The technology, called the Viral-Engineered RNA-based Activation System (VERAS), hijacks the virus's own replication ...

Advancing RNA therapeutics depends on understanding two critical questions: Where do drug candidates go, and what do they do ...

Discover how AI is revolutionizing RNA drug development in a new article published in Engineering. Learn about the potential ...

Certain guanine-rich regions of the transcriptome can fold up into four-stranded structures called RNA G-quadruplexes that are thought to have harmful effects in living cells. Both eukaryotes and ...

This is where the Nottingham team, led by Dr Aditi Borkar, Assistant Professor in Molecular Biochemistry & Biophysics in the School of Veterinary Medicine and Science, has achieved a transformative ...

Studying a trio of non-coding RNA molecules produced abundantly in bacterial cells, a SLAC/Stanford-led research team discovered extravagant, multistrand complexes made entirely of RNA—structures they ...

In the realm of modern medicine, RNA-based therapies have emerged as a promising avenue, with significant advancements in metabolic diseases, oncology, and preventive vaccines. A recent article ...

Using a novel method, Weizmann Institute of Science researchers map 16 types of simultaneous changes in dozens of samples; ...