纵观整项研究，我们不仅看到了FOCAS这一强大工具的威力，更看到了它所揭示的生物学复杂性。过去针对m6A的抗癌策略往往类似于“地毯式轰炸”（如全局抑制METTL3或FTO），虽然有效，但伴随着破坏管家功能的风险。

Advancing RNA therapeutics depends on understanding two critical questions: Where do drug candidates go, and what do they do ...

12月31日，北京大学以“FOCAS: Transcriptome-wide screening of individual m6A sites functionally dissects epitranscriptomic control of ...

Here, we address the barriers in integrating WGTS for cancer diagnostics and treatment selection and answer questions regarding utility in different cancer types, cost-effectiveness and affordability, ...