Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding ...

Human stem cells can differentiate into any human cell. But the process of dedifferentiation, essentially differentiation in reverse, is implicated in several diseases. Now researchers have uncovered ...

Peroxisomes are essential cell organelles that play a vital role in lipid metabolism and cellular detoxification. To perform ...

The enzyme PI3K plays a critical role in cell migration. Scientists have long understood this function. But researchers have recently unveiled that a subunit of this enzyme also has the ability to ...

Cryo-EM reconstructions of the human ATR–ATRIP complex show how clinical small-molecule inhibitors like VE-822 and RP-3500 bind to and inhibit ATR activity. A research team led by Prof. Gang Cai and ...

Long interspersed nuclear element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human genome—comprising about 17% of the genome. It is commonly called a "jumping gene" or ...

UPTON, NY—Scientists studying a COVID-19 coronavirus enzyme at temperatures ranging from frosty to human-body warm discovered subtle structural shifts that offer clues about how the enzyme works. The ...

The function of an enzyme, critical to most forms of life, has been revealed. A research team, led by the John Innes Centre found that the enzyme DNA topoisomerase VI (topo VI) performs a critical ...

This story is one in a series marking International Women and Girls in Science Day. Join us as we celebrate some laboratory leaders taking research to new heights. Enzymes are the fundamental stuff of ...

Researchers have identified what may be the key molecular mechanism responsible for COVID-19 mortality -- an enzyme related to neurotoxins found in rattlesnake venom. An enzyme with an elusive role in ...